Shimeshi is about a unique restaurant that accepts only one customer a day. It is called "Le Bon Vivre", tucked away in some back alley of the bustling city, that serves "lost food." Not anyone can easily get a reservation. That person has to have circumstances or are struggling on which path to take, and are currently at the crossroad of his life. Not only that, he must request for a dish that's lost in this world, a dish that has a significance in his life and now only exists in his memory. The staff of "Le Bon Vivre" consists of Terayashiki Renichi (Murakami Jun), the chef who has a discerning skill in reproducing dishes that are lost in this world; Oze Kiyoi (Hayashi Kento), the second chef who is responsible for researching recipes and information regarding the requested dishes; and Ikeyama Juri (Manaka Ayu), the owner and maître d'hôtel of "Le Bon Vivre". The three will do their best to recreate this lost dish, and serve it to their guests.
Kurumi Ichiki (Ayame Gouriki) is 25-years-old. When she was young, she went to France. Now, after she came back to Japan, she works as a waitress at high end traditional restaurant (ryotei). She is talented with cooking.
Meanwhile, Prime Minister Ichiro Ato (Fumiyo Kohinata) and Executive Secretary of Prime Minister Seiji Koga (Kenichi Takito) decide to hire a cook for the prime minister's residence for the first time in 70 years. Due to an incident, Seiji meets Kurumi Ichiki and discovers that she has a natural talent for cooking. Seiji asks her to be a cook for the Prime Minister. After a hesitation, Kurumi Ichiki says yes. She begins work at the prime minister's residence, but she struggles in a hostile environment with the chef and his subordinates at the restaurant of the prime minister's official residence.
Misaki Sakurai (Mirei Kiritani) has not dated in a long time. She has focused on her work as a pâtissier to eventually run her own business. One day, she gets fired from work. She then meets her first love from high school Chiaki Shibasaki (Shohei Miura). Misaki Sakurai works part-time at Chiaki’s restaurant and also stays there. While she lives with Chiaki at his restaurant, she realizes that Chiaki's two younger brothers Toma (Shuhei Nomura) and Kanata (Kento Yamazaki) also live there.