Takeo Goda (Ryohei Suzuki) is a high school student 2 m tall and weighting more than 100 kg. He has a righteous character. The male students adore him, but female students do not like him. All of the girls Takeo likes prefer his handsome friend Makoto Sunakawa (Kentaro Sakaguchi).
One day, Takeo saves female high school student Rinko Yamato (Mei Nagano) from a pervert on train. Takeo falls in love with her at first sight. He feels Rinko likes Makoto, but Makoto isn't the one she likes. Takeo struggles to liaise between Rinko and Makoto.
Moritaka Mashiro (Takeru Satoh) doesn't want to follow in the path of his uncle who worked as a manga artist, but ultimately died because of exhaustion. Moritaka Mashiro figures he will graduate from school and work at an office. Things change though when falls in love with a girl at school. The girl, who hopes to become a voice actress, tells Moritaka they can marry, but only after they both achieve their dreams. Moritaka then teams up with fellow classmate Akito Takagi (Ryunosuke Kamiki) to publish their first manga.
Yu Akabane (Nana Komatsu) moves to a dormitory room after her father's transfer from work. She is excited that she will live in the same dorm as Takumi Shirakawa (Yudai Chiba) aka "White Prince." Yet, Haruto Kurosaki (Kento Nakajima) aka "Black Devil" kisses her as punishment for going against him. It is Yu Akabane’s first kiss. Since then, she becomes obedient to Haruto Kurosaki.
Erika Shinohara (Fumi Nikaido) is a first year of high school student. While talking to friends, she makes up a story about her "boyfriend." In reality, Erika Shinohara doesn't have a boyfriend. Erika's friends soon begin to doubt her story and Erika is also running out of lies. Erika then sees a pretty boy on the street and takes his picture discreetly. She later shows his picture to her friends as her boyfriend. The boy in the picture is Kyouya Sata (Kento Yamazaki) and happens to attend the same school as Erika. She tells Kyouya about her situation and asks him to be her pretend boyfriend. Even though Kyouya has a pretty appearance, he has a dark side.
A mysterious creature destroys 70% of the moon. The creature then warns that if he is not destroyed by March of next year, Earth will be next. The creature also demands that he becomes the homeroom teacher for 3rd grade E class at Kunugigaoka Junior High School. The government is powerless to say no.
The creature then becomes the homeroom teacher of 3rd grade E class which consists of failed students including Nagisa Shiota (Ryosuke Yamada). The creature is called Teacher Koro.
Meanwhile, the government requests that the students try to kill Teacher Koro even though he possesses super powers. The government offers a 10 billion yen reward for whomever successfully kills him. The students are confused by the situation, but decide to kill Teacher Koro.
When their class begins with Teacher Koro, the students finds themselves having a good time with their new teacher.
Ayumi Nitta (Erika Toda) suffers from anthropophobia (extreme shyness & fear of people). She works as a janitor at a hospital. One evening, she has an one night stand with surgeon Wataru Makino (Tori Matsuzaka) who is addicted to sex. Ayumi later realizes she is now pregnant because of that one night stand. When she tells Wataru that she is pregnant, Wataru believes she is a making a bad April Fools joke. Wataru Makino then takes flight attendant Reiko (Nanao) out to an Italian restaurant. He doesn't know that Ayumi Nitta is also going to the same restaurant.
The story centers around Ann Kaede (Kana Hanazawa), a picture book writer and her father (Shigemitsu Ogi). Returning from New York, Ann found herself unable to come up with anything to write. To add to her sorrow, her beloved cat, Pero, went missing. She frantically looked for Pero, but what waited for her was something that would change her world. Just what is it?
Sixth grader Ayase Chihaya, a tomboy with no ambitions or goals of her own, gets to know Wataya Arata, a transfer student at Chihaya's elementary school and an outcast. Through Arata, Chihaya picks up karuta and they form a team with their other friend and classmate Mashima Taichi. After graduating elementary school, Chihaya continues to play karuta hoping for a chance to meet Arata again after he went back to Fukui to take care of his sick grandfather. As time passed and Chihaya enters high school, she starts a karuta club with Taichi so that they can finally meet Arata again.